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KMID : 0370220110550060473
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Yakhak Hoeji
2011 Volume.55 No. 6 p.473 ~ p.477
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Study on the Acetylcholinesterase Inhibitory Activity of Coumarin Derivatives
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Nam Seung-Ok
Yun Yong-Don
Park Dong-Hyun
Ryu Gong-Hun
Lee Yong-Sup
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Abstract
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Alzheimer’s disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.
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KEYWORD
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acetylcholinesterase, Alzheimer’s disease, inhibitor, coumarin, scopoletin, memory
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